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Home arrow People arrow Faculty Tuesday, 24 November 2009

CRAIG V. BYUS, PH.D.

Dean and Program Director

Professor of Biomedical Sciences and Biochemistry

Ph.D., University of New Hampshire, Durham

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Research Summary

Research is concerned with the molecular mechanisms involved in the regulation of cell growth and proliferation, particularly as this process relates to cancer. Various important enzyme systems involved with polyamine metabolism are being studied with biochemical and molecular biological techniques in order to design both nutritional and new drug therapies for the prevention and treatment of cancer.

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Publications

Stagg, R.B., Hawel, L. III, Pastorian, K., Cain, C., Adey, W.R. and Byus, C.V.Effect of immobilization and concurrent exposure to a pulse-modulated microwave field upon core body temperature, plasma ACTH and corticosteroid and brain ornithine decarboxylase, c-Fos, and c-Jun mRNA.Radiation Res. 155: 584-592, 2001. Pastorian, K.E., Hawel, L. III, and Byus, C.V. Identification of putrescine-responsive mRNA's in Chinese hamster ovary cells using representational difference analysis. Biochemica Biophysica Acta 1524: 131-142, 2000.

Pastorian, K.E., Hawel, L. III and Byus, C.V. Optimization of cDNA representational difference analysis for the identification of differentially expressed mRNA's. Analytical Biochemistry 283: 89-98, 2000.

Adey, W.R., Byus, C.V., Cain, C.D., Higgins, R.J., Jones, R.A., Kean, C.J., Kuster, N., MacMurray, A., Stagg, R.B. and Zimmerman, G. Spontaneous and nitrosourea-induced primary tumors of the central nervous system in Fischer 344 rats exposed to frequency-modulated microwave fields. Cancer Res. 60: 1857-1863, 2000.

Adey, W.R., Byus, C.V., Cain, C.D., Higgins, R.J., Jones, R.A., Kean, C.J., Kuster, N., MacMurray, A., Stagg, R.B., Zimmerman, G. and Haggren, W. Spontaneous and nitrosourea-induced primary tumors of the central nervous system in Fischer 344 rats chronically exposed to 836 MHz modulated microwaves. Radiation Res. 152: 292-302, 1999.

Fukumoto, G.H. and C.V. Byus. Putrescine export in Xenopus laevis occurs against a concentration gradient: Evidence for a non-diffusional export process. Biochem. Biophys. Acta 1324: 215-222, 1997.

Pastorian, K.E. and C.V. Byus. Tolerance to putrescine toxicity in Chinese hamster ovary cells is associated with altered uptake and export. Exp. Cell. Res. 231: 284-295, 1997.

Fukumoto, G.H. and C.V. Byus. A kinetic characterization of putrescine and spermidine uptake and export in human erythrocytes. Biochem. Biophys. Acta 1282: 48-56, 1996.
 
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