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Home arrow People arrow Faculty Tuesday, 24 November 2009

PAUL M. QUINTON, PH.D.

Professor of Biomedical Sciences, UCR
Nancy MacCracken Chair in Pediatric Pulmonary Medicine
Department of Pediatrics, UCSD School of Medicine
Ph.D., Rice University, Houston

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Research Summary

Our laboratory is located in the research complex of the UCSD Hillcrest Hospital in San Diego. We focus on the basic defects and malfunctions associated with the hereditary disease cystic fibrosis (CF), which is due to an abnormal impermeability to anions. Biomedical research activity on CF has exploded during the past decade such that virtually all areas of medical science have been brought to bear in this disease. Our expertise is in fluid and electrolyte transport, which requires electrophysiological techniques to explore these problems; we also employ ratiometric fluorescence, immunocytochemical and molecular biology approaches. We generally investigate freshly isolated living human tissues such as sweat glands and small airways – two tissues characteristically affected in CF. Current areas of investigation include: control of Cl- and Na+ ion channels, control and composition of human airway fluids, and processes controlling HCO3- movements through the anion channel affected in cystic fibrosis, CFTR. 		 Image
 
Publications

Best JA, Quinton PM: Simple Salivary Secretion Assay for Drug Efficacy for Cystic Fibrosis. Exp Physiol In Press.

Wang X, Lytle C, Quinton PM: Predominant constitutive CFTR conductance in small airways. Respir Res 2005, 6(1):7.

Wang XF, Reddy MM, Quinton PM: Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts. Exp Physiol 2004, 89(4):417-425.

Quinton PM: Estructura y Propriedades del regulador de la conductancia de transmembrana de Fibrosis Quística (CFTR). In: Fibrosis Quistica. Edited by Ed. E. Segal AF, and F. Rentería, 1 edn. Buenos Aires: Ediciones Journal, 2004; 2004: 15-46.

Reddy MM, Quinton PM: Control of dynamic CFTR selectivity by glutamate and ATP in epithelial cells. Nature 2003, 423:756 - 760.

Reddy M, Quinton M: Functional interaction of CFTR and ENaC in sweat glands. Pflugers Arch 2003, 445(4):499-503.

Reddy MM, Quinton PM: Effect of anion transport blockers on CFTR in the human sweat duct. J Membr Biol 2002, 189(1):15-25.

Bovell DL, Quinton PM: The immunocytochemical localisation of anion exchangers (AE) in the reabsorptive duct of the human eccrine sweat gland. J Physiol (Lond) 2002, 544P:107P.

Reddy MM, Sun D, Quinton PM: Apical heterotrimeric g-proteins activate CFTR in the native sweat duct. J Membr Biol 2001, 179(1):51-61.

Reddy MM, Quinton PM: cAMP-independent phosphorylation activation of CFTR by G proteins in native human sweat duct. Am J Physiol Cell Physiol 2001, 280(3):C604-613.

Quinton PM: The neglected ion: HCO3. Nat Med 2001, 7(3):292-293. Reddy MM, Light MJ, Quinton PM: Activation of the epithelial Na+ channel (ENaC) requires CFTR Cl- channel function. Nature 1999, 402(6759):301-304.
 
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