UCR Division of Biomedical Sciences - Daniel S. Straus, Ph.D.

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Sunday, 22 November 2009

DANIEL S. STRAUS, PH.D.

Professor of Biomedical Sciences and Biology

Ph.D., University of California, Berkeley

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Research Summary

Research in my lab is focused on an improved understanding of molecular mechanisms for regulation of mammalian gene expression. We are currently studying the anti-inflammatory and anti-cancer activity of ligands for the PPAR nuclear receptors. Our studies of inflammation utilize mice in which the interleukin 10 gene is knocked out. These mice spontaneously develop inflammatory bowel disease with immunopathology similar to Crohn's disease in humans. We have recently demonstrated that the PPARγ ligand rosiglitazone has therapeutic activity in this mouse model. Our studies of the anti-cancer activity of PPAR ligands are currently centered on multiple myeloma and other hematological malignancies.

Publications

Straus, D.S. 2009. Design of small molecules targeting transcriptional activation by NF-kappaB: overview of recent advances. Expert Opinion on Drug Discovery 4: 823-836.

Bajwa, P.J., Lee, J.W., Straus, D.S., and Lytle, C. 2009. Activation of PPAR gamma by rosiglitazone attenuates intestinal Cl^- secretion. Am. J. Physiol. Gastrointest. Liver Physiol. 297: G82-G89.

Lee, J.W., Wang, P., Kattah, M.G., Youssef, S., Steinman, L., DeFea, K. and Straus, D.S. 2008. Differential regulation of chemokines by IL-17 in colonic epithelial cells. J. Immunol. 181: 6536-6545.

Ye, J., Lee, J.W., Presley, L.L., Bent, E., Wei, B., Braun, J., Schiller, N.L., Straus, D.S. and Borneman, J. 2008. Bacteria and bacterial rRNA genes associated with the development of colitis in IL-10^-/-mice. Inflammatory Bowel Diseases 14:1041-1050.

Straus, D.S. and Glass, C.K. 2007 Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms. Trends in Immunology 28: 551-558.

Bajwa, P.J., Alioua, A., Lee, J.W., Straus, D.S., Toro, L., and Lytle, C. 2007 Fenofibrate inhibits intestinal Cl^- secretion by blocking basolateral KCNQ1 K⁺ channels. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G1288-G1299.

Lee, J., Bajwa, P.J., Carson, M.J., Jeske, D.R., Cong, Y., Elson, C.O., Lytle, C. and Straus, D.S. 2007. Fenofibrate represses interleukin-17 and interferon-γ expression and improves colitis in interleukin-10-deficient mice. Gastroenterology 133: 108-123.

Lytle, C., Tod, T.J., Vo, K.T., Lee, J.W., Atkinson, R.D. and Straus D.S. 2005. The peroxisome proliferator-activated receptor gamma ligand rosiglitazone delays the onset of inflammatory bowel disease in mice with interleukin 10 deficiency. Inflammatory Bowel Diseases 11: 231-243.

Campo, P.A., Das, S., Hsiang, C-H., Bui, T., Samuel, C.E. and Straus. D.S. 2002. Translational regulation of cyclin D1 by 15-deoxy-Δ12-14-prostaglandin J2. Cell Growth & Differentiation 13: 409-420.

Hsiang, C-H. and Straus, D.S. 2002. Cyclopentenone causes cell cycle arrest and represses cyclin D1 promoter activity in MCF-7 breast cancer cells. Oncogene 21: 2212-2226.

Straus, D.S. and Glass, C.K. 2001. Cyclopentenone prostaglandins: New insights on biological activities and cellular targets. Medicinal Research Reviews 21: 185-210.

Straus, D.S., Pascual, G., Li, M., Welch, J.S., Ricote, M., Hsiang, C.-H., Sengchanthalangsy, L.L., Ghosh, G. and Glass, C.K. 2000. 15-Deoxy-D12,14-prostaglandin J2 inhibits multiple steps in the NF-kB signaling pathway. Proc. Natl. Acad. Sci. USA 97: 4844-4849.

Marten, N.W., Hsiang, C.-H., Yu, L., Stollenwerk, N.S. and Straus. D.S. 1999. Functional activity of hepatocyte nuclear factor-I is specifically decreased in amino acid-limited hepatoma cells. Biochim. Biophys. Acta 1447: 160-174.

Hsiang, C.H., Marten, N.W. and D.S. Straus. 1999. Upstream region of rat serum albumin gene promoter contributes to promoter activity: presence of functional binding site for hepatocyte nuclear factor-3. Biochem. J. 338: 241-249.

Bui, T. and D.S. Straus. 1998. Effects of cyclopentenone prostaglandins and related compounds on insulin-like growth factor-I and Waf1 gene expression. Biochim. Biophys. Acta 1397: 31-42.

Bui, T., C. Kuo, P. Rotwein and D.S. Straus. 1997. Prostaglandin A2 specifically represses insulin-like growth factor-I gene expression in C6 rat glioma cells. Endocrinology 138: 985-993.

Marten, N.W., F.M. Sladek and D.S. Straus. 1996. Effect of dietary protein restriction on liver transcription factors. Biochemical J. 317: 361-370.

Hayden, J.M. and D.S. Straus. 1995. Insulin-like growth factor-I and serine protease inhibitor 2.1 nuclear transcript abundance in rat liver during protein restriction. J. Endocrinology 145: 397-407.

Straus, D.S. and E.J. Burke. 1995. Glucose stimulates IGF-I gene expression in C6 glioma cells. Endocrinology 136: 365-368.

Straus, D.S., N.W. Marten, J.M. Hayden and E.J. Burke. 1994. Protein restriction specifically decreases the abundance of serum albumin and transthyretin nuclear transcripts in rat liver. J. Nutrition 124: 1041-1051.

Marten, N.W., E.J. Burke, J.M. Hayden and D.S. Straus. 1994. Effect of amino acid limitation on the expression of nineteen genes in rat hepatoma cells. FASEB J. 8: 538-544.

Hayden, J.M., N.W. Marten, E.J. Burke and D.S. Straus. 1994. The effect of fasting on insulin-like growth factor-I nuclear transcript abundance in rat liver. Endocrinology 134: 760-768.

Straus, D.S. 1994. Nutritional regulation of hormones and growth factors that control mammalian growth. FASEB J. 8: 6-1.

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